| 摘要 |
<p>A compound of formula (I), in which: ring A is one of the five alternative multi-cyclic rings as shown wherein a dotted line adjacent to a bond indicates that a single bond or a double bond may be present at that position; R1 is 2-oxazoline, 2-imidazoline or 2-thiazoline; R is hydrogen, lower straight or branched chain alkyl of 1 to 6 carbon atoms, or lower straight or branched chain alkenyl of 2 to 6 carbon atoms, a cycloaliphatic ring of 3 to 6 carbon atoms, phenyl optionally mono- or di-substituted with hydroxy, halogen, alkyl of 1 to 3 carbon atoms or alkoxy of 1 to 2 carbon atoms, or methylenedioxyphenyl; or a stereoisomer, or a pharmaceutically acceptable salt thereof. These compounds have α2 receptor blocking activity and hence find use in the treatment or palliation of mental depression, elevated intraocular pressure, non insulin-dependent diabetes, male impotence and obesity. Further, these compounds and their primary amine precursors, represented in formula (I) when R1 is hydrogen are useful as neuroprotective agents in the mammalian nerve cells of the eye and brain.</p> |
