| 发明名称 |
A PROCESS FOR THE PREPARATION AND SEPARATION OF DIASTEREOMERIC SALTS OF FOLINIC ACID |
| 摘要 |
A process for the preparation, separation and purification of (6S) and (6R) diastereomers of folinic acid salts with at least dibasic amines is disclosed, which process comprises the hydrolysis of (6RS)-5,10-methenyl-5,6,7,8-tetrahydrofolic acid chloride hydrochloride with an at least dibasic amine and the subsequent separation of the diastereomeric salts.
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| 申请公布号 |
WO9533749(A1) |
申请公布日期 |
1995.12.14 |
| 申请号 |
WO1995EP02073 |
申请日期 |
1995.05.31 |
| 申请人 |
BRACCO S.P.A.;DIBRA S.P.A.;FELDER, ERNST;RIPA, GIORGIO;DISTASO, CARLO |
发明人 |
FELDER, ERNST;RIPA, GIORGIO;DISTASO, CARLO |
| 分类号 |
C07B57/00;C07D475/04;(IPC1-7):C07D475/04 |
主分类号 |
C07B57/00 |
| 代理机构 |
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