发明名称 |
POLYPEPTIDES FOR DIAGNOSING INFECTION WITH TRYPANOSOMA CRUZI |
摘要 |
Polypeptides are disclosed that are useful for diagnosing American Trypanosomiasis, or Chagas disease, a disease caused by the infectious agent Trypanosoma cruzi. The polypeptides have a sequence that corresponds to the amino acid sequence of at least one of the C-terminal and N-terminal nonrepetitive regions of TCR27 protein. The polypeptide additionally may comprise an amino acid sequence of one or more repeats from the central region of TCR27 protein. In a preferred embodiment, the polypeptide corresponds to the N-terminal nonrepetitive region of TCR27 protein and at least one repeat from the central region of TCR27 protein, and does not correspond to the C-terminal nonrepetitive region. The polypeptides may further comprise a linker sequence at either the N-terminus or the C-terminus to facilitate attachment or conjugation to a carrier molecule in a liquid or solid support system for use in a sensitive assay for detecting T. cruzi infection.
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申请公布号 |
WO9525797(A1) |
申请公布日期 |
1995.09.28 |
申请号 |
WO1995US03191 |
申请日期 |
1995.03.20 |
申请人 |
KIRCHHOFF, LOUIS, V.;OTSU, KEIKO |
发明人 |
KIRCHHOFF, LOUIS, V.;OTSU, KEIKO |
分类号 |
A61P33/02;C07K14/44;C12N15/30;(IPC1-7):C12N15/30;C12N15/62;C12N15/54;C12N1/21;C12N9/10;G01N33/577 |
主分类号 |
A61P33/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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