PREPARATION OF 3-ISOTHIAZOLON COMPOSITION

摘要

PURPOSE: To produce a stabilized biocidal and water-soluble 3-isothiazolone composition substantially free from nitrosamine impurity and nitrosamine precursor material. CONSTITUTION: This method for producing 3-isothiazolone composition comprises a step for forming 3-isothiazolone by amidating a mixture of dimethyl-3,3'- dithiodipropionate with methyl-3-mercaptanepropionate (a nucleophilic scavenger) to provide an intermediate amide, and cyclizing the intermediate amide with a chlorinating agent, a step for adding a metal nitrate as a stabilizer to the formed 3-isothiazolone to provide the objective 3-isothiazolone composition containing 5-chloro-2-methyl-4-isothiazolin-3-one as an active ingredient.