摘要 |
An imidazoline derivative represented by general formula (1), wherein R<1> represents a water- or fat-soluble substituent, in particular, carboxyl or carbomethoxy, or a pharmaceutically acceptable salt group thereof. A process for producing the same. A blood pressure retentive containing as the active ingredient the above imidazoline derivative or another imidazoline derivative wherein R<1> in formula (1) represents hydrogen. The above imidazoline derivative is a novel substance, and both this compound and the imidazoline derivative wherein R<1> represents hydrogen are useful as the blood pressure retentive for treating hypotensive shock by removing excessive NO which is the substantial ingredient of a vascular smooth muscle relaxant (EDRF). <CHEM> |