The present invention relates to recombinant mycobacteria, particularly recombinant M. bovis BCG, which express heterologous DNA encoding a product (protein or polypeptide) of interest, such a protein or polypeptide (e.g., an antigen) against which an immune response is desired or a cytokine.
申请公布号
WO9503418(A3)
申请公布日期
1995.03.02
申请号
WO1994US08215
申请日期
1994.07.22
申请人
BETH ISRAEL HOSPITAL ASSOCIATION;WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH