摘要 |
The intermediate 1-[3-acetylthio-2(s)-methylpropanoyl]-1-proline is prepared by reacting L-proline with (R)-3-acetylthio-2-methyl propanoyl chloride at 0-5 DEG C., with pH controlled at 7.5-8.5, using 2.5M potassium hydroxide and potassium phosphate buffer, which gives >97% pure material after crystallizing from the reaction mixture.
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