| 摘要 |
PCT No. PCT/EP91/00350 Sec. 371 Date Oct. 28, 1991 Sec. 102(e) Date Oct. 28, 1991 PCT Filed Feb. 26, 1991 PCT Pub. No. WO91/13055 PCT Pub. Date Sep. 5, 1991.Aryl- and heteroarylethenylene derivatives of formula <IMAGE> (I) wherein Y is a mono- or bicyclic ring system chosen from (A), (B), (C), (D), (E), (F) and (G) <IMAGE> (A) <IMAGE> (B) <IMAGE> (C) <IMAGE> (D) <IMAGE> (E) <IMAGE> (F) <IMAGE> (G) R is a group of formula <IMAGE> (e) R1 is hydrogen, C1-C6 alkyl or C2-C6 alkanoyl; R2 is hydrogen, halogen, cyano or C1-C6 alkyl; n is zero or an integer of 1 to 3: n is zero or an integer of 1 to 3 when Y is a ring system (A); it is zero, 1 or 2 when Y is a ring system (B), (E), (F) or (G); or it is zero or 1 when Y is a ring system (C) or (D); and the pharmaceutically acceptable salts thereof; and wherein each of the substituents R, OR1 and R2 may be independently on either of the aryl or heteroaryl moieties of the bicyclic ring system (A), (E), (F) and (G), whereas only the benzene moiety may be substituted in the bicyclic ring system (B), are useful as tyrosine kinase activity inhibitors.
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