CLONED HUMAN ALPHA1C ADRENERGIC RECEPTOR

摘要

The human adrenergic receptor of the alpha1C subtype is cloned and used in an in vitro assay to screen for compounds that specifically bind to the human alpha1C adrenergic receptor, including compounds effective to reduce symptoms of benign prostatic hypertrophy. The invention includes the assay, the cloned human receptor used in the assay, an isolated human alpha1C adrenergic receptor free of other human proteins, and compounds identified through the use of this novel, cloned receptor, which selectively bind the human alpha1C adrenergic receptor.