Naphthothiopyranone derivatives

摘要

PCT No. PCT/JP91/00825 Sec. 371 Date Dec. 11, 1992 Sec. 102(e) Date Dec. 11, 1992 PCT Filed Jun. 20, 1991 PCT Pub. No. WO92/00294 PCT Pub. Date Jan. 9, 1992.A naphthothiopyranone derivative represented by the formula: <IMAGE> (wherein R1 is a hydrogen atom or an alkyl group having 1 to 4 carbon atoms) and an acid addition salt thereof have more excellent antagonist effect at serotonin 3 receptors than the prior art compounds and the effects based thereon, e.g. anti-vomiting effect, gastrointestinal movement regulating effect and anti-anxiety effect.