Polysubstituted 2-amido thiazoles derivatives, process for their preparation, pharmaceutical compositions and utilization for the preparation of a medicament.

摘要

The subject of the invention is the use of a compound of formula in which Y represents a 3-quinolyl group or a 2-indolyl group of formula: in which: - R is hydrogen, an acetyl group or a CH2COOR' group, R' being hydrogen or a C1-C4 alkyl; - X is a (hetero)aryl radical chosen from 4-chloro-2,6-dimethoxyphenyl, 2,6-dimethoxy-4-methylphenyl, 2,4,5-trimethoxyphenyl, 4-methyl-2,3,6-trimethoxyphenyl, 2,6-dimethoxy-4-ethylphenhyl, 2,4,6-trimethoxy-5-chlorophenyl, 2,4,6-trimethoxy-3-pyridyl, 2,4-dimethoxy-6-methyl-3-pyridyl, 6-chloro-2,4-dimethoxy-5-pyrimidrimyl, 2,4,6-trimethoxy-5-pyinidinyl, 5-chloro-2,4-dimethoxyphenyl, 5-chloro-2-methoxy-4-methylphenyl, 2,5-dimethoxy-4-methylphenyl, 4-trifluoromethyl-2,6-dimethoxyphenyl, 2,4-dimethoxy-5-methylphenyl, 5-ethyl-2,4-dimethoxyphenyl or 2,4-dimethoxyphenyl groups; - Z represents H, a C1-C4 alkyl or a benzyl; with the restriction that Z is necessarily hydrogen when X is a phenyl radical simultaneously substituted in the 2- and 6-positions or when X is a 3-pyridyl radical simultaneously substituted in the 2- and 4-positions or when X is a 5-pyrimidinyl radical simultaneously substituted in the 4- and 6-positions.