发明名称 |
Antibacterial cephalosporin compounds |
摘要 |
There are presented antibacterial cephalosporins having broad antimicrobial activity as well as intermediates for their formation, such compounds having the formula <IMAGE> I wherein R is hydrogen or a carboxylic acid-protecting group; R1 is a substituted piperazinium group of the formula <IMAGE> in which Q represents a substituted quinolinyl or naphthyridinyl group and the piperazine nucleus may be optionally substituted with one or more lower alkyl groups; R2 is selected from the group consisting of hydrogen, lower alkoxy, lower alkylthio and amido; R3is hydrogen or an acyl group; and m is 0, 1 or 2, preferably 0; as well as the corresponding readily hydrolyzable esters, pharmaceutically acceptable salts and hydrates of these compounds.
|
申请公布号 |
US5329002(A) |
申请公布日期 |
1994.07.12 |
申请号 |
US19900549674 |
申请日期 |
1990.07.06 |
申请人 |
HOFFMANN-LA ROCHE INC. |
发明人 |
ALBRECHT, HARRY A.;KEITH, DENNIS D.;WEI, CHUNG-CHEN;WEIGELE, MANFRED;YANG, ROXANA |
分类号 |
C07D501/06;A61K31/546;C07D501/18;C07D501/34;C07D501/46;C07D519/00;(IPC1-7):C07D501/14;A61K31/545 |
主分类号 |
C07D501/06 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|