| 发明名称 |
New substituted azetidinones as anti-inflammatory and antidegenerative agents. |
| 摘要 |
<p>Substituted azetidinones of the general Formula (I) which have been found to be potent elastase inhibitors and thereby useful anti-inflammatory and antidegenerative agents, <CHEM> wherein R4 is (a) <CHEM> b) <CHEM> where Rx is carboxy C1-6alkyl, benzyloxycarbonylC1-3alkyl, or t-butoxycarbonylC1-3alkyl, wherein Q is a covalent bond or <CHEM> Y is <CHEM> or <CHEM> or a covalent bond.</p> |
| 申请公布号 |
EP0595557(A1) |
申请公布日期 |
1994.05.04 |
| 申请号 |
EP19930308421 |
申请日期 |
1993.10.22 |
| 申请人 |
MERCK & CO. INC. |
发明人 |
DOHERTY, JAMES B.;FINKE, PAUL E.;DORN, CONRAD P.;MACCOSS, MALCOLM;DURETTE, PHILIPPE L.;MILLS, SANDER G.;SHAH, SHRENIK K.;LANZA, THOMAS J.;SAHOO, SOUMYA P.;HAGMANN, WILLIAM K.;HALE, JEFFREY J. |
| 分类号 |
A61K31/395;A61K;A61K31/397;A61K31/40;A61K31/44;A61K31/4427;A61K31/443;A61K31/445;A61K31/455;A61K31/495;A61K31/505;A61K31/53;A61K31/535;A61K31/55;A61P7/00;A61P9/10;A61P11/00;A61P29/00;A61P35/02;A61P43/00;C07D;C07D205/08;C07D401/12;C07D403/12;C07D405/12;C07D413/12;C07D417/12;C07D453/02;C07D521/00;(IPC1-7):C07D205/08 |
主分类号 |
A61K31/395 |
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