6-amino-6-desoxyfumagillols, production and use thereof

摘要

The present invention relates to a compound of the formula: <IMAGE> (I) wherein R1 is 2-methyl-1-propenyl group or isobutyl group; R2 and R3 are each hydrogen atom, an optionally substituted hydrocarbon residue or an optionally substituted acyl group or R2 and R3 may form a ring together with the adjacent nitrogen atom; and the bonding mark DIFFERENCE represents an alpha -linkage or beta -linkage, or a salt thereof. The compound (I) of the present invention has, among others, angiogenesis inhibiting activity, cell-growth inhibiting activity and immune reaction inhibiting activity, thus being useful as medicines, etc.