PROCESS FOR THE BIOTECHNOLOGICAL PREPARATION OF L-THIENYLALANINES IN ENANTIOMERICALLY PURE FORM FROM 2-HYDROXY-3-THIENYLACRYLIC ACIDS, AND THEIR USE

摘要

1 Process for the biotechnological preparation of L-thi-enylalanines in enantiomerically pure form from 2hydroxy-3-thienylacrylic acids, and their use L-Thienylalanines are prepared via the hydantoin or the azlactone route. The starting substances used for the biotransformation are 2-hydroxy-3-thienylacrylic acids. The innovative step consists in the transamination of the enol form of the 2-hydroxy-3-thienylacrylic acids to give L-thienylalanines with the aid of biotransformation. The transaminiation is carried out in the presence of L-aspartic acid or L-glutamic acid as amino donor.