A universal vaccine is disclosed which elicits a protective immune response in different host species and against different coronaviruses. A polypeptide which elicits protective antibodies against a homologous sequence found in the C terminal portion of coronavirus S proteins is disclosed. Vaccines comprising either the polypeptide or nucleic acids which encode the polypeptide are also disclosed. Methods of protecting a host against coronavirus infection are disclosed.
申请公布号
WO9323421(A1)
申请公布日期
1993.11.25
申请号
WO1993US04365
申请日期
1993.05.07
申请人
SMITHKLINE BEECHAM CORPORATION
发明人
MILLER, TIMOTHY, J.;KLEPFER, SHARON;REED, ALBERT, PAUL;JONES, ELAINE, V.