New and known 4-hydroxy-6-fluoroalkyl-pyrimidine cpds.

摘要

(A) 4-Hydroxy-6-(pentafluoroethyl)pyrimidine (Ia) is new. (B) Prodn. of 4-hydroxy-6(perfluoroalkyl)pyrimidines of formula (I) is effected by reacting an alkyl 2-(perfluoroalkanoyl)acetate of formula RCOCH2CCOR1 (II) with a formamidine salt of formula (III) in the presence of an alkali metal alkoxide, (NH4)2CO3 or an alkali metal carbonate: R = CF3 or C2F5; R1 = 1-4C alkyl; X = acetate or chloride.