发明名称 |
C-21 hydroxylated FK-506 antagonist |
摘要 |
Described is a process for producing a new FK-506 antagonist agent, a C-21 hydroxylated analog of FR-900520 under novel fermentation conditions utilizing the novel microorganism, Streptomyces hygroscopicus (Merck Culture Collection MA 6832) ATCC No. 55166. The macrolide antagonist is useful in preventing and/or counteracting accidental or inadvertent FK-506 overdosage in an FK-506 therapeutic program designed to prevent autoimmune diseases or human host rejection of foreign organ transplants, e.g. bone marrow, liver, lung, kidney and heart transplants.
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申请公布号 |
US5225403(A) |
申请公布日期 |
1993.07.06 |
申请号 |
US19910720550 |
申请日期 |
1991.06.25 |
申请人 |
MERCK & CO., INC. |
发明人 |
TREIBER, LASZLO R.;DEZENY, GEORGETTE;COLWELL, JR., LAWRENCE F.;ARISON, BYRON H.;DUMONT, FRANCIS |
分类号 |
A61K31/435;C07D498/18;C12P17/18 |
主分类号 |
A61K31/435 |
代理机构 |
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代理人 |
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地址 |
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