Systems and methods for predicting response to minoxidil for the treatment of androgenetic alopecia

摘要

A method for selecting a treatment for a subject suffering from androgenetic alopecia is disclosed. The method comprises performing an assay to measure minoxidil sulfotransferase activity in the sample of one or more hair follicles or a scalp biopsy previously obtained from the subject, thereby generating an activity value indicative of the minoxidil sulfotransferase activity level in the sample; comparing the activity value to one or more standardized activity values with each standardized activity value representing either high or low expected minoxidil response for hair re-growth or retention for a class of patients including the subject, thereby producing an indication of either high or low expected minoxidil response for hair re-growth or retention for the subject at a particular dosage of minoxidil; and presenting the indication to the subject.