| 摘要 |
<p>An antifungal compound represented by formula (I), wherein X is independently both F or both Cl or one X is F and the other is Cl; Y = (a), (b), (c), (d), (e), (f) or (g); R' = (C1-C10)alkyl, (C2-C10)alkenyl, (C2-C10)alkynyl, (C3-C8)cycloalkyl or CH2R?2; R2 = (C¿1-C3)perhaloalkyl, CO2R3, *CH(OR4)CH2OR4 or CH¿2?N(R?5); R3¿ = lower alkyl or H; R4 = R3 or (CH¿2?)2OR?3; R5¿ = lower alkyl; Z = H or (C¿1?-C5)alkanoyl and the carbons with the asterisks (*) have the R or S absolute configuration; or a pharmaceutically acceptable salt thereof as well as pharmaceutical compositions containing them and a method of treating or preventing fungal infections in mammals using them are disclosed.</p> |
