发明名称 |
Tri-substituted tetrahydrofuran antifungals. |
摘要 |
<p>An antifungal compound represented by formula ÄIÜ: <CHEM> wherein X is independently both F or both Cl or one X is F and the other is Cl; Y= <CHEM> R' = (C<5>-C<5><4>) alkyl; (C<6>-C<5><4>)alkenyl; (C<6>-C<5><4>)alkynyl; (C<7>-C3/4 )cycloalky or CH<6>R<2>; R<2> = (C<5>-C<7>)perhaloalkyl; CO<6>R<3> *CH(OR4)CH<6>OR4 or CH<6>N(R5) R<3> = lower alkyl or H R4 = R<3> or (CH<6>)<6>OR<3> R5 = lower alkyl Z=H, or (C<5>-C psi ) alkanoyl and the carbons with the asterisks (*) have the R or S absolute configuration; or a pharmaceutically acceptable salt thereof as well as pharmacetical compositions containing them and a methods of treating or preventing fungal infections in mammals using them are disclosed.</p> |
申请公布号 |
EP0539938(A1) |
申请公布日期 |
1993.05.05 |
申请号 |
EP19920118413 |
申请日期 |
1992.10.28 |
申请人 |
SCHERING CORPORATION |
发明人 |
SAKSENA, ANIL K.;GIRIJAVALLABHAN, VIYYOOR M.;GANGULY, ASHIT K.;LOVEY, RAYMOND G. |
分类号 |
C07D405/06;A61K31/41;A61K31/495;A61K31/496;A61K31/54;A61P31/04;A61P31/10;C07D207/09;C07D249/08;C07D249/12;C07D295/096;C07D403/10;C07D405/14;C07D417/14;C07D521/00 |
主分类号 |
C07D405/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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