摘要 |
<p>3,5-Dihydroxyheptanoic acid derivatives of formula (I) and formula (II) have an inhibition effect on HMG-CoA reductase, a cholesterol value reduction effect, and an antioxidation function, thus serving as cholesterol reducing agent or lipid reducing agents: <CHEM> wherein R<1> represents hydrogen, a nitro group, or -N(R4)R5 in which R4 and R5 each represent an alkyl group, an alkenyl group, an aryl group, an aralkyl group; an acyl group, an aroyl group, a carbamoyl group, or a thiocarbamoyl group, and R4 and R5 may be combined to form a cyclic amino group; and R<2> and R<3> each represent hydrogen or an alkyl group; and R6 represents hydrogen, an alkyl group, an alkali metal, or an alkaline earth metal.</p> |