发明名称 |
PAPUA NEW GUINEA HUMAN T-LYMPHOTROPIC VIRUS |
摘要 |
The present invention relates to a human T-cell line (PNG-1) persistently infected with a Papua New Guinea (PNG) HTLV-I variant and to the infecting virus (PNG-1 variant). Cells of the present invention express viral antigens, type C particles and have a low level of reverse transcriptase activity. The establishment of this cell line, the first of its kind from an individual from Papua New Guinea, makes possible the screening of Melanesian populations using a local virus strain. The present invention also relates to vaccines for use in humans against infection with and diseases caused by HTLV-I and related viruses. The invention further relates to a variety of bioassays and kits for the detection and diagnosis of infection with and diseases caused by HTLV-I and related viruses. |
申请公布号 |
AU2475392(A) |
申请公布日期 |
1993.03.16 |
申请号 |
AU19920024753 |
申请日期 |
1992.08.12 |
申请人 |
THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEP |
发明人 |
RICHARD YANAGIHARA;VIVEK R. NERURKAR;CAROL JENKINS;MARK A. MILLER;RALPH M. GARRUTO |
分类号 |
A61K39/00;C07K14/15;C07K16/10;C12N7/00 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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