| 摘要 |
2110725 9301165 PCTABS00019 Compounds of formula (I) and salts and prodrugs thereof wherein, Q is optionally substituted phenyl, heteroaryl or naphthyl; X and Y are each H, C1-6 alkyl, C2-6 alkenyl or X and Y are together =O; Z is O or S; R1 is H, optionally substituted C1-6 alkyl, optionally substituted phenyl(C1-4 alkyl), C2-6 alkylene, COC1-6 alkylhalo, CORa, COORa, CONHRa, COC1-6alkylNRaRb or CONRaC1-6alkylCONRaRb; R2 is substituted C1-6 alkyl, optionally substituted phenyl(C1-4 alkyl), C2-6 alkylene, C1-6alkylhalo, CORa, COORa, CONHRa, COC1-6alkylNRaRb or CONRaC1-6alkylCONRaRb; or R1 and R2 together form a chain (CH2)p optionally substituted by oxo; R3 is H or C1-6 alkyl; R4 is H, C1-6 alkyl or phenyl; and R5 is optionally substituted (CH2)qphenyl; are tachykinin antagonists useful for treating pain.
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