| 摘要 |
Novel inositol phosphorothioates, useful for conducting research into the biochemistry of inositol phosphate esters, have the general formula I: C6H6 (OH)n ¢(OPO2S)2!m ¢OPO2O)2-!6-m-n (I) in which n is zero or an integer from 1 to 5 and, m is an integer from 1 to 6. They may be prepared by a method comprising reacting an inositol derivative having the general formula II: C6H6 (OB)n ¢OP(OCH2CH2CN)2!6-n (II) in which n is zero or an integer from 1 to 5 and B represents a hydroxyl-protecting group, with a solution of elemental sulphur, which may or may not be radioactive, in a solvent therefor, and removing the hydroxyl-protecting groups from the product of the reaction. Phosphate esters may be prepared by oxidizing the compound of formula II with an organic peroxide. |
