| 摘要 |
This invention encompasses compounds of the formula: <IMAGE> where X, Y, Z, T, R1, R3, R4, and R5 are variables representing various organic and inorganic substituents; M is <IMAGE> R2 and R6 represent hydrogen or alkyl substituents; or R1 and R2 together may represent -(CH2)n1 where n1 is 1, 2, or 3; or NR4R5 represents substituted or unsubstituted-tetrahydroisoquinolinyl; or <IMAGE> where n is 1, 2, or 3; W is N or CH; and R7 represents hydrogen or aryl; or W-R7 is oxygen or sulfur. These compounds are highly selective partial agonists or antagonists at brain dopamine receptor subtypes or prodrugs thereof and are useful in the diagnosis and treatment of affective disorders such as schizophrenia and depression as well as certain movement disorders such as Parkinsonism. Futhermore compounds of this invention may be useful in treating the extraparamidyl side effects associated with the use of conventional neuroleptic agents.
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