| 摘要 |
PURPOSE:To produce the antithrombotic material which maintains a stable antithrombotic property over a long period of time by covalent bonding the amino group of a polyvinyl chloride(PVC) polymer and the one terminal glycidyl group of polyethylene glycol diglycidyl ether, then covalent bonding the other terminal glycidyl group and the amino group of heparin. CONSTITUTION:The amino group of the PVC polymer introduced with the amino group and the one terminal glycidyl group of the polyethylene glycol diglycidyl ether are first covalent bonded in order to produce the antithrombotic medical treating material. The PVC polymer introduced with the amino group is brought into contact with an aq. soln. of the polyethylene glycol diglycidyl ether for this purpose. The soln. is thereafter brought into contact with the aq. heparin soln., by which the other terminal glycidyl group and the amino group of the heparin are covalent bonded. The resulted antithrombotic treating material has the excellent adhesiveness to the base material and exhibits the antithrombotic property over a long period of time. In addition, the elution of the heparin is obviated. |
