Novel 15-nitro-2beta, 3beta-dihydro- and 15-nitro-2beta,3beta,6,7-tetrahydrotabersonine derivatives, pharmaceutical compositions containing them and process for preparing same.

摘要

The invention relates to novel 15-nitro-2 beta ,3 beta -dihydro- and 15-nitro-2 beta ,3 beta ,6,7-tetrahydrotabersonine derivatives of the formula (I), <CHEM> wherein R<1> stands for hydrogen; R<2> stands for hydrogen or a C1-6alkyl group; and the symbol @ @ represents a single or double bond as well as their salts. The invention further relates to pharmaceutical compositions containing the above compounds as well as a process for the preparation of the above compounds of formula (I) and of the pharmaceutical compositions. The compounds of formula (I) exert a reducing or inhibitory effect on cerebral edema and show antihypoxic properties. Thus, they are useful for the prevention or treatment of brain injuries of various origin induced by hypoxia of the brain.