| 摘要 |
Substituted six-membered benzo-fused heterocycles of the formula (I) <IMAGE> in which: X=0, NH, S->(O)n (n=0 or 2); R1 is phenyl, phenyl substituted by methoxy, hydroxy, chlorine, fluorine, diethylaminoethoxy, phenoxy, 2-methyl-4-thiazolyl, 2-amino-4-thiazolyl, phenyl, amino, nitro, terbutyl, carboxymethyl, acetamido, dimethyltriazenyl, benzoyl, hexyl, undecyl, trifluoromethyl, carbamoyl; or R1 is trifluoromethyl, pyridyl-2,pyridyl-4; R2 is H, methoxy, hydroxy; or R1 and R2 are -CH=CH-CH=CH-; R3 and R4 are methoxy, hydroxy, fluorine or form a fused benzene ring; CR5R6R7 is carboxymethyl, -CH2-PO3H,-CH2-PO(oET)2, 4-methylpiperazinyl, aminomethyl,3-4-5-trimethoxyphenylaminomethyl, acetyl, bromoacetyl, hydroxyethyl, acetoxyethyl, mercaptomethyl, acetylthiomethyl, methoxy-carbopnylthiomethyl, -CH-CONH2, <IMAGE> substituted thiazolyl, subsituted furanone, imidazo(1,2-a)pyridinyl, indolizinyl, or R4 and R5 form a fused benzene ring on the positions 5 and 6, 6 and 8 or 7 and 8 are disclosed. These compounds possess anticancer activity in particular antipancreatic cancer activity together with immunomodulating activity.
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