| 摘要 |
3,5-Dihydroxypentanoic acid derivatives are provided which are 6-hydroxy-8-(2,2-dimethyl-1-oxybutoxy-2-methyl)-substituted-thiazolidine derivatives and have the structure <IMAGE> wherein Z is <IMAGE> R6 is an alkali metal, lower alkyl or H; R1 and R2 are the same or different and are H, lower alkyl or aryl; X is S, O, <IMAGE> or a single bond; R7 is lower alkyl; R3 is lower alkyl or aryl; R4 and R5 are the same or different and are H or lower alkyl; and --- represents a single bond or a double bond, and are HMG CoA reductase inhibitors and thus are useful as antihypercholesterolemic agents and in treating atherosclerosis, and also as antifungal agents. In addition, novel intermediates for use in preparing the above mevinic acid derivatives are also provided.
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