| 摘要 |
<p>A molecule comprising a first region which binds to a tumour (preferably the receptor for uPA) and a second region which inhibits a (preferably tumour-associated) protease, for example uPA. The first and second regions may be respective antibodies or parts thereof specific for appropriate parts of uPAR and uPA. Preferably, the first region is a uPAR-binding part of uPA, e.g. the 12-32 region theeof, and the second region is PAI-2 or a uPA-inhibiting analogue or part thereof, and the first and second regions are combined to form a single polypeptide, expressible from a transformed host.</p> |
