HUMAN MACROPHAGE INFLAMMATORY PROTEIN 2.BETA.

摘要

2086088 9200326 PCTABS00010 An attempt to identify the human counterpart of murine macrophage inflammatory protein 2 unexpectedly resulted in not one but two candidate sequences, designated hu-MIP-2.alpha. and hu-MIP-.beta., respectively. By using the DNA sequences and recombinant systems provided by this invention, one can obtain hu-MIP-2.beta., one of the two human counterparts to mMIP-2, substantially free of other human protein. This invention also provides antibodies reactive with hu-MIP-2$(b) polypeptides as well as immunoassay methods for determining hu-MIP-2.beta. and nucleotide probes for detecting nucleotide sequences encoding hu-MIP-2.beta. in biological samples.