4-METHYLENE-1-OXA-2-OXO-8-AZASPIRO(4,5)DECANE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESSES FOR PREPARING THEM

摘要

4,4-disubstd piperidine derivs of formula (I) and their acid addn and quaternary ammonium salts are new. In (I) R1 = H or C0NHR; R = H, 1-12C alkyl, 3-6C cycloalkyl or a carboxyclic 6-10C aryl or carbocycline (6-10C aryl) 1-4C alkyl opt ring substd by one or more halo, 1-4C alkyl or 1-4C alkoxy; R2 = ethynyl or C0CH3; Ph1 and Ph2 = phenyl opt substd by one or more halo, 1-4C alkyl, 1-4C alkoxy, trihalo or 0H opt esterified by a 1-4C alkansic acid; n = 1-2. - 3 Cpds (I) ie 1-(3,3-bis(4-fluorophenyl)-2-propenyl)-4 ethynyl-4-hydroxypiperidine hydrochloride, (Ib) 1-(4,4-bis(4-fluorophenyl)-3- butenyl)-4-ethynyl-4-hydroxy piperidine hydrochloride (Ia) and 1-(4,4-bis(4-fluorophenyl)-3- butenyl)-4-benzylcarbamoyloxy-4 ethynylpiperidine are specifically claimed.