发明名称 |
METHOD FOR RADIOLABELING MONOVALENT ANTIBODY FRAGMENTS |
摘要 |
A method for radiolabeling a monovalent Fab or Fab' antibody fragment which comprises the steps of cleaving a divalent F(ab)2 or F(ab')2 antibody fragment using sulfite or meta-bisulfite ions to produce a monovalent fragment having a free sulfhydryl group, and contacting the monovalent fragment with a cation of a metallic radionuclide which binds to sulfhydryl groups, without removing excess sulfite or meta-bisulfite.
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申请公布号 |
CA2082265(A1) |
申请公布日期 |
1991.11.08 |
申请号 |
CA19912082265 |
申请日期 |
1991.03.05 |
申请人 |
IMMUNOMEDICS, INC. |
发明人 |
CHANG, CHIEN-HSING;JONES, ANASTASIA L. |
分类号 |
A61K51/00;A61K38/00;A61K51/10;C07K16/06;G01N33/534;G01N33/68;(IPC1-7):G01N33/534;G01N33/563 |
主分类号 |
A61K51/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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