发明名称 Stabilized pharmaceutical composition and its production.
摘要 <p>The pharmaceutical composition of the invention, which comprises a benzimidazole compound of the formula <CHEM> wherein R<1> is hydrogen, alkyl, halogen, cyano, carboxy, carboalkoxy, carboalkoxyalkyl, carbamoyl, carbamoylalkyl, hydroxy, alkoxy, hydroxyalkyl, trifluoromethyl, acyl, carbamoyloxy, nitro, acyloxy, aryl, aryloxy, alkylthio or alkylsulfinyl, R<2> is hydrogen, alkyl, acyl, carboalkoxy, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, alkylcarbonylmethyl, alkoxycarbonylmethyl or alkylsulfonyl, R<3> and R<5> are the same or different and each is hydrogen, alkyl, alkoxy or alkoxyalkoxy, R<4> is hydrogen, alkyl, alkoxy which may optionally be fluorinated, or alkoxyalkoxy, and m is an integer of 0 through 4, and a basic inorganic salt of magnesium and/or a basic inorganic salt of calcium, is physically stable.</p>
申请公布号 EP0446961(A2) 申请公布日期 1991.09.18
申请号 EP19910105959 申请日期 1987.02.13
申请人 TAKEDA CHEMICAL INDUSTRIES, LTD. 发明人 MAKINO, TADASHI;TABATA, TETSURO;HIRAI, SHIN-ICHIRO
分类号 A61K9/16;A61K9/20;A61K9/50;A61K31/44;A61K47/02;C07D401/12 主分类号 A61K9/16
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