RIBOZYMES, PRODUCTION AND USE

摘要

Synthetic RNA molecules having highly specific endoribonuclease activity (hereinafter referred to as "ribozymes") are described. The ribozymes comprise a hybridizing region which is complementary in nucleotide sequence to at least part of a target RNA, and a catalytic region which is adapted to cleave the target RNA. Methods for inactivating RNA, and compositions containing ribozymes are also described.