发明名称 |
ESTERS OF CASTANOSPERIME IN THE TREATMENT OF CEREBRAL MALARIA |
摘要 |
Red blood cells which are infected with the parasite P. falciparum cause the cells to become sticky and less deformable. This results in a build-up of cells on the vascular wall and creates occulsions to blood flow which are thought to cause the cerebral, renal and liver complications of P. falciparum infections. Certain esters of castanospermine prevent or reduce the adhesion of falciparum infected blood cells to the vascular endothelial wall and are a useful adjunct in the treatment of malaria. |
申请公布号 |
ZA9008134(B) |
申请公布日期 |
1991.07.31 |
申请号 |
ZA19900008134 |
申请日期 |
1990.10.11 |
申请人 |
MERRELL DOW PHARMACEUTICALS INC. |
发明人 |
ALAN JOSEPH BITONTI;PETER PAUL MCCANN;ALBERT SJOERDSMA |
分类号 |
C07D471/04;A61K31/36;A61K31/435;A61K31/445;A61P33/02 |
主分类号 |
C07D471/04 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|