发明名称 |
Modified nucleotide compounds. |
摘要 |
<p>Disclosed is a nuclease resistant nucleotide compound capable of hybridizing with a complementary RNA in a manner which inhibits the function thereof, which modified nucleotide compound includes at least one component selected from the group consisting of MN3M, B(N)xM and M(N)xB wherein N is a phosphodiester-linked modified or unmodified 2'-deoxynucleoside moiety; M is a moiety that confers endonuclease resistance on said component and that contains at least one modified or unmodified nucleic acid base; B is a moiety that confers exonuclease resistance to the terminus to which it is attached; x is an integer of at least 2.</p> |
申请公布号 |
EP0431523(A2) |
申请公布日期 |
1991.06.12 |
申请号 |
EP19900123109 |
申请日期 |
1990.12.03 |
申请人 |
ENZO BIOCHEM, INC. |
发明人 |
BRAKEL, CHRISTINE L.;WETMUR, JAMES G.;QUARTIN, ROBIN S. |
分类号 |
C07H21/04;A61K31/70;A61P31/12;C07H21/00 |
主分类号 |
C07H21/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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