| 摘要 |
The compounds may find application in human medicine. The method consists of a single stage and produces no isomeric 3-substituted oxasolo(4,5-b)-pyridine-2(3H)-ones, but only 4-substituted derivatives with the following common formula.<IMAGE>where if n is equal to 1, then X is equal to 0, NOH, NNH2, NNHCONH2 or NNHC6H5, and if n is equal to 2, then X is 0, NOH, NNH2, NNHCONH2. According to the method, the starting oxasolo(4,5-b)-pyridine-2(3H)-on is stirred at room temperature with a halogenoacteone in aqueous medium in the presence of equimolar amount of potassium hydroxide, or is boiled in acetonitrile with methylvinylketone in the presence of triethylamine as a catalyst. After that, the product is reacted with hydroxylamine hydrochloride, hydrazine and semicarbazide to the corresponding oximes, hydrazones, and semicarbazones.
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