| 摘要 |
New spasmolytic active tertiary amine derivatives, salts thereof, and processes for their preparation, of the formula 1 are described 1 in which the groups R represent a range of possibilities, typically hydrogen or an alkyl or alkylene group; A is a phenyl or heteroaryl group having 5 or 6 members; Z is the group NR12 or an oxygen atom, R12 being hydrogen or alkyl; n is zero or 1; and X is a carbonyl, thiocarbonyl or SO2 group. In the compounds wherein R4 is other than hydrogen, the S-configuration of the chiral center is preferred. A typical compound is These compounds do not exhibit the peripheral and central muscarinolytic side effects characteristic of other neurotropic spasmolytics, for example atropine and secorerine. |
