Cyclohexanol derivatives, production and use thereof.

摘要

The present invention relates to a compound of the formula: wherein A is halogen, N(O)mR<1>R<2>, N<(+)>R<1>R<2>R<3>.X<(-)>, S(O)nR<1> or S<(+)>(O)mR<1>R<2>.X<(-)> where R<1>,R<2> and R<3> are each optionally substituted hydrocarbon or heterocyclic group, X<(-)> is a counter anion; m is an integer of 0 or 1; n is an integer of 0 to 2; R<1> and R<2> may form a nitrogen-containing or a sulfur-containing heterocyclic ring, which may further form a condensed ring, with the adjacent nitrogen atom or sulfur atom, and these nitrogen-containing or sulfur-containing heterocyclic rings may have substituents, B is O or NR<4> where R<4> is hydrogen or an optionally substituted lower alkyl or aryl group, D is 2-methyl-1-propenyl group or isobutyl group, and E is hydrogen, an optionally substituted hydrocarbon or an optionally substituted acyl group; provided that, when A is chlorine, E is an optionally substituted hydrocarbon or acyl excepting dinitrobenzoyl, a salt thereof, production and use thereof. The novel cyclohexanol derivatives of the present invention have angiogenesis inhibiting activity and anti-tumor activity, and they are used as anti-rheumatic agents, therapeutic agents of psoriasis, therapeutic agents of diabetic retinopathy and anti-tumor agents.