HEMOGLOBIN COMBINED WITH A POLY(ALKYLENE OXIDE)

摘要

There is disclosed hemoglobin modified in that a poly(alkylene oxide) is bonded thereto by a bond between a terminal group of said poly(alkylene oxide) and an amino group of said hemoglobin, said bond having the structure:
-CH2-O-(CH2)-CONH-Hb
wherein Hb represents said hemoglobin and n represents a positive integer, preferably 1 to 7. The modified hemoglobin is an effective oxygen carrier and can therefore be used as a blood substitute.