STABLE,COVALENTLY-COUPLED,POLYSACCHARIDE-PROTEIN CONJUGATES COMPRISING NEUTRAL POLYSACCHARIDES AND IMMUNOGENIC PROTEINS COUPLED THROUGH BIGENERIC SPACERS,METHODS FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

摘要

Covalently-modified neutral bacterial polysaccharides; covalent conjugates of such polysaccharides linked by a bigeneric spacer, with immunogenic bacterial membrane or other proteins, which conjugates are useful components of bacterial vaccines; and methods of preparing such polysaccharides and conjugates.