THROMBOLYTIC AGENTS WITH MODIFIED KRINGLE DOMAINS

摘要

This invention is related to analogs of thrombolytic agents having a modified kringle domain. More specifically this invention is directed to TPA type compounds wherein modifications in the kringle 1 and kringle 2 domains occur. This invention is also directed to analogs with one or more changes in the kringle domain of urokinase-type compounds. The compounds of this invention are pharmaceutically useful having particular use in the same manner as TPA and urokinase.