| 摘要 |
Pharmaceutically useful optically active alpha -arylalkanoic acids or esters, ortho esters, or amides thereof are stereoselectively prepared by contacting an aryl magnesium Grignard reagent with an optically active alpha -substituted acyl halide to form the optically active aryl alpha -substituted alkyl ketone, which is ketalized and rearranged to the desired optically active alpha -arylalkanoic acid or the corresponding ester, ortho ester or amide. In an alternate embodiment, the aryl alpha -substituted alkyl ketone is reduced to the corresponding alkanol, which is rearranged to the alpha -arylalkanal. The alkanal so produced is converted to the desired optically active alpha -arylalkanoic acid by conventional methods.
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