1,2,3,4-TETRAHYDROISOQUINOLINE DERIVATIVES

摘要

The invention relates to 1,2,3,4-tetrahydroisoquinoline derivatives represented by following general formula (I) and antitumor effect potentiators containing said compounds as active ingredients. In the said formula, R<2> represents a lower alkyl group or, when combined with R<1> or R<3>, represents a methylene group, one of R<1> and R<3> represents a lower alkyl group or, when combined with R<2>, represents a methylene group, and the other represents a lower alkenyl group, a substituted or unsubstituted aryl-lower alkenyl group, a substituted or unsubstituted aryl-lower alkyl group (provided that an unsubstituted phenyl group is omitted), a substituted or unsubstituted aryl group (provided that an unsubstituted phenyl group is omitted) or a group represented by -(CH2)m-A (wherein A represents a halogen atom, a lower alkylthio group, a lower alkylsulfinyl group, a lower alkylsulfonyl group, a substituted or unsubstituted aryl-lower alkylthio group, a substituted or unsubstituted aryl-lower alkylsulfinyl group, a substituted or unsubstituted aryl-lower alkylsulfonyl group, a substituted or unsubstituted arylthio group, a substituted or unsubstituted arylsulfinyl group, a substituted or unsubstituted arylsulfonyl group, a substituted or unsubstituted alkyloxy group or a substituted or unsubstituted aryloxy group, an N-benzyl-N-(lower alkyl)amino group, an N-phenyl-N-(lower alkyl)amino group, an N,N-di(lower alkyl)amino group, a di(lower alkyloxy)phosphinoyl group or a dibenzyloxyphosphinoyl group, and m represents 2 to 4), R<4> represents a lower alkyl group, Ar represents a phenyl group optionally substituted by 1 to 3 lower alkyloxy groups, and n represents 0 to 2.