| 摘要 |
<p>NEW MATERIAL:The 4-cyano-2-azetidinone derivative of formulaI(R<1> is amino which may be acylated or protected; X is H or methoxy; W is H or sulfo). EXAMPLE:(3S, 4RS)-4-Cyano-3-tritylamino-2-azetidinone. USE:An intermediate of 4-substituted-2-azetidinone derivative, an antibacterial agent and a beta-lactamase-inhibiting agent. PROCESS:The compound of formulaIis prepared by reacting the compound of formula II[R<2> is same as R<1>; X is H or methody; W is H or sulfo; Y is halogen, group of formula -OCOR<3> (R<3> is hydrocarbon group), -SCOR<3>, or formula III (n is 1 or 2)]with a cyano compound, and if necessary, eliminating the protecting group from the product.</p> |
