Process for the preparation of cephalosporin derivatives

摘要

The present invention relates to an improved process for producing cephalosporin derivatives of formula (I), the 3-position of which being substituted by acetoxymethyl or tetrazolylthiomethyl and the 7-acyl group of which being substituted by D-mandelic acid derivatives, which comprises simultaneously reacting the compound of formula (III) with the compound of formula (IV) in the presence of a compound of formula (II) and anamine in high yield, <IMAGE> (I) <IMAGE> (II) <IMAGE> (III) <IMAGE> (IV) wherein, R1 is hydrogen or <IMAGE> R2 is methyl, ethyl, propyl or phenyl, X is <IMAGE>