| 摘要 |
<p>A cinnamoylamide derivative of the general formula: <CHEM> [wherein, (i) R<1>, R<2> and R<3>, which may be the same or different, each represents a halogen atom, a straight-chain or branched-chain alkoxy group of from 1 to 7 carbon atom(s), a straight-chain or branched-chain alkyl group of from 1 to 7 carbon atom(s) or a nitro group, and one of R<4> and R<5> represents a methyl group and the other represents a hydrogen atom, or (ii) one of R<1>, R<2> and R<3> represents 4-isobutyl, 4-butyl, 4-propyl, 4-butoxy or 4-sec-butyl, and the other two each represent a hydrogen atom, R<4> represents a methyl group and R<5> represents a hydrogen atom] and non-toxic salts thereof possess inhibitory activity on 5 alpha -reductase, indicative of utility for treating and/or preventing alopecia, acne or prostatic hypertropy. E</p> |
