| 摘要 |
PURPOSE:To economically obtain the titled compound of good quality useful as medicines without using expensive chemicals, by thermally reacting benzoic acids with urea in a molten state using cobalt acetate and boric acid together as a catalyst. CONSTITUTION:Benzoic acids are thermally reacted with urea in a molten state to afford benzonitriles. In the process, cobalt acetate and boric acid are used together as a catalyst. The cobalt acetate is preferably added in an amount of about 0.1-5wt.%, particularly about 0.3-3wt.% expressed in terms of cobalt acetate tetrahydrate. the boric acid is preferably added in an amount of about 0.1-5wt.%, particularly about 0.3-3wt.% expressed in terms of orthoboric acid. The reaction is carried out at >=about 160 deg.C, particularly about 180-210 deg.C in the former stage thereof and the temperature is increased to >=220 deg.C, preferably 230-280 deg.C in the latter stage thereof. |
